The skin is daily subjected to various stresses, such as pollution, cigarette smoke, UVA, UVB… which alter cells.

WE PROPOSE THE USE OF AUTOPHAGY AND/OR MITOPHAGY AS A NEW LINE OF SUBSTANTIATION

These cell recycling/detoxification pathways represent markers for monitoring the impact of these stresses on cells.

Indeed an aggression will stimulate these paths. A protective product may prevent the formation of damaged material within the cell and thus limit the activation of autophagy and mitophagy.

Specific markers are:
– LC3B, autophagy central protein,
– P62, main substrate,
– PINK1, mitophagy specific marker.

Additional markers such as MT1H, AhR, NRF2, HO-1, MDA… can also be studied in parallel to support your results.

BIO-EC Laboratory proposes to objectify the efficacy of your products through autophagy and / or mitophagy against environmental aggressions using:
– l’utilisation de la Pollubox® (Pollubox® newsletter),
– UVs irradiation.

To know more ask us our special Autophagy newsletter and do not hesitate to contact us for any information or request for a quote.

The BIO-EC laboratory participates in the 24th edition of the IFSCC which will take place from 23 to 25 October in Seoul!

You will be able to discover our 4 posters:

• “Development of a new model of air pollution”
• “Nanoparticles detection and follow-up in the human skin explant”
• “The Solarbox, an innovative device to investigate the effect of the blue light on the ex vivo skin explants”
• “Immediate effects of cosmetics on skin surface highlighted by nanoscale topography on ex vivo human skin”

Do not hesitate to contact us for the pdf version of these posters if you want to know more!