BIO-EC laboratory always looking for innovation to bring you the best solutions is invested in many collaborative research projects.


  • 2016-2019

The project S’KIN is a FUI project certified by cosmetic valley and Lyon Biopôle which is conducted by BIO-EC laboratory, Chimex, Dermadis, Labo-BF and SATIE laboratory from Cergy-Pontoise University.

This three years- project which has started in 2017, aims to develop et commercialise new anti-protease cosmetic ingredients to treat the cutaneous disorders of sensitive skin, atopic-like or with acne or rosacea. The characterization of these products will be performed using new cutaneous biological models mimicking the sensitive skin disorders, as well as using innovative measurement systems.

BIO-EC laboratory was financed by La région Ile de France.


  • 2016-2018

The physiology of human body is highly affected by abiotic stresses from the external environment including UVs, extreme temperatures and atmospheric pollutants.

Atmospheric pollutants include polycyclic aromatic hydrocarbons (PAHs) volatile organic compounds (VOCs) and fine particle pollution (PM10 and PM2.5).

The main goal of the UrbaSkin project, a project labeled by the competitive pole of Cosmetic Valley, is to analyze and characterize the impact of atmospheric pollution on human skin biology and physiology in order to develop new cosmetic products with anti-pollution activity.

BIO-EC laboratory is the leader of this multi-disciplinary research project.

Other partners are two research units from the academic area: the Glyco-Mev laboratory of Rouen University and URCOM laboratory from Le-Havre University and three private companies working in the dermo-cosmetic field: BIO-EUROPE (Solabia Group) laboratory, GENEX laboratory and the Uriage Dermatological Laboratories.


  • 2014-2017

Glycoskin I is a research project about the identification of new active substances (phosphosaccharides) and formulae acting on a non-exploited modulation pathway of the cutaneous pigmentation with simultaneously the development of tests and the realization of measures.

The project is run by Libragen Company, which is specialized in the development via biocatalysis (green chemistry) of glycoconjugate molecules which will find an application in dermocosmetics.

Partners are « Glycobiology and Cell recognition » team from Molecular and Biophysics center, UPR4301, CNRS, Orléans, Tebu-bio Company specialized in safety test and in vitro substantiation, BIO-EC Laboratory whose expertise is the substantiation on human living skin explants, GlycoDiag Company specialized in the identification of cellular glycanes and finally, the Ales group for his know-how in active galenic formulation with a strong penetrating power and devoid of surfactants.

The originality of this collaborative project lives in the fact that it addresses a subject of research completely in adequacy with the demands of a world market always more applicant, and it joins almost all the jobs by the value chain of the cosmetic sector for the elaboration of innovative cosmetics and by using it the green chemistry.


  • 2012-2017

The Blue Hyal project objective is to structure know-how on the modulation of polysaccharides from micro seaweeds with the aim of the realization, customized, of “greens” polysaccharides with high application specificity such as stabilizers of emulsion, anti UV or hydrating activity support which will be the first products developed during the program.

Based on exclusive exopolysaccharides of micro seaweeds and stemming from the R&D of our partners, those products will position as “green” substitute of the hyaluronique acid and analogues from not renewable GMO resources.

Products development will involve a pushed study of the biotechnological ways of modification of polysaccharides as well as their functionalization and reticulation by soft chemistry more particularly bu the ground-frost process (SG).

Products will be characterized by a physico-chemical point of view and a biological activity, by using and by optimizing new non-destructive systems of on-line measure and new tests of cosmetics substantiation on human living skin explants. A study of the modalities of industrializations according to the sustainable development will be realized, with the design and pilots’ realization of production and their optimization. Cosmetic qualification (activity on finished product, safety study) will be conduce on the resultant products as well as an environmental impact study and a cost estimate of industrial production.


  • 2011-2015

The project ALOCA 2 is a FUI project certified by Cosmetic Valley which was conducted by BIO-EC laboratory, the “institut européen de Biologie” of the group UNIPEX/ Lucas Meyer Cosmetics, Alès groupe, and the institutions of INSERM (with Sabouraud center) and of ICSN/ CNRS.

During these four years-project (2011-2015), transcriptomics and protein analyses, performed in vivo, in vitro and ex vivo, allowed us to figure out the biological mechanisms involved in hair loss (alopecia) and hair graying. The results were described in scientific publications and communications.

This project resulted also in new tests applied for the characterization of alopecia and hair graying, as well as the development of new cosmetic active ingredients efficient against these hair disorders; commercially available and/or patented.

BIO-EC laboratory was financed by BPI France.


  • 2009-2012

The Skin-O-Flor project, a project labeled by the competitive pole of Cosmetic Valley, has been realized in collaboration between 5 different laboratories including two research units of Rouen University: the Glyco-Mev laboratory and LSMS laboratory.

Three additional laboratories, including BIO-EC laboratory, BIOEUROPE laboratory (Solabia Group) and the Uriage Dermatological Laboratories have participated at this project.

The project allowed developing new cosmetics for healthy sensitive skins to maintain and improve the organic-physic-chemical barriers properties of the healthy sensitive skin in front of its microbial environment.

BIO-EC Laboratory thanks to its dermocosmetic expertise, participated actively in the various stages of the SKIN O Flor project, and more particularly it contributed to develop the following stages:

  • Study of the skin flora, thanks to surface stripping realized on volunteers recruited by BIO-EC.

  • Molecular response analyze, from cutaneous cell after human living skin explants treatment with 3 different germs: epidermidis, S .aureus and P. fluorescens.

  • Analyze of different glycomelcules effects on the cutaneous defense link with the microbiota.

  • Raman spectroscopy analyze of normal skin and sensitive skin treated or not with corporal milk and cleaning oil “Xemose” conditioned by LDU.


Non-exhaustive list of publications produced by BIO-EC:


Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality – Part 1 : ex vivo safety evaluation

V. Zvezdin*, L. Peno-Mazzarino†, N. Radionov†, T. Kasatkina‡ and I. Kasatkin‡

*Microneedles Inc, 919 North Market Street, Wilmington Delaware, 19801, USA,

†Laboratoire BIO-EC, Chemin de Saulxier 1, Longjumeau 91160,

‡Microneedle Industrial LLC, Bolshoy Boulevard, 42, Moscow 121205, Russia

Journal of Cosmetic Science, 2020, 1-8


Seaberry (Hippophae rhamnoides L.) and Water Lily (Nymphaeaceae) Extracts Protect Human Skin against Blue Light, Environmental Pollutants and UV-A Irradiations in an Ex VivoModel System.

Mohamed Softa1, Percoco Giuseppe2, Almeida Scalvino Stéphanie2, Peno-Mazzarino Laurent2, Pauline Bony1, Lati Elian2

1 INDERMA dermatological laboratory, Ivry sur Seine, France

2 BIO-EC laboratory, Longjumeau, France

Journal of Cosmetics, Dermatological Sciences and Applications, 2019, 9, 244-262


Birch sap (Betulaalba) and Chaga Mushroom (Inonotusobliquus) Extracts Show Anti-Oxidant, Anti-Inflammatory and DNA Protection/Repair Activity In Vitro

Mohamed Softa1, Giuseppe Percoco2, Elian Lati2, Pauline Bony1

1 INDERMA dermatological laboratory, Ivry sur Seine, France

2 BIO-EC laboratory, Longjumeau, France

Journal of Cosmetics, Dermatological Sciences and Applications, 2019, 9, 188-205


Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation.

Almeida Scalvino S1, Chapelle A2, Hajem N3, Lati E1, Gasser P1, Choulot JC3, Michel L4,Hocquaux M5, Loing E6, Attia J5, Wdzieczak-Bakala J2 

1 Laboratoire BIO-EC, 91160, Longjumeau, France

2 ICSN, UPR2301 CNRS, 91198, Gif-sur-Yvette, France

3 Ales Groupe, 95871, Bezons, France

4 Inserm UMR976, 75475, Paris, France

5 IFF-Lucas Meyer Cosmetics, 31036, Toulouse, France

6 IFF-Lucas Meyer Cosmetics, G1V4W2, Québec, Canada

Int J Cosmet Sci.2018 Oct;40(5):516-524


Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin

Narda M1, Peno-Mazzarino L2, Krutmann J3,4, Trullas C1, Granger C1

1 Innovation and Development, ISDIN, Barcelona, Spain

2 Laboratoire BIO-EC, 91160, Longjumeau, France

3 Leibniz Research Institute for Environmental Medicine, and Medical Faculty, Deanery of Medicine, University of Düsseldorf, Düsseldorf, Germany

4 Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

Skin Pharmacol Physiol. 2018;31(6):324-331


Modèle d’explants de peau humaine

Peno-Mazzarino Laurent, Percoco Giuseppe, Almeida Scalvino Stéphanie, Gasser Philippe, Lati Elian

Chapitre 10, pp : 159-185. In Modèle pour l’évaluation des produits cosmétiques. Cosmétique Valley Editions. 


Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

L. Michel1,2§†, P. Reygagne3†, P. Benech4,5†, F. Jean-Louis1,2, S. Scalvino6, S. Ly Ka So1, Z. Hamidou3, S. Bianovici3, J. Pouch7, B. Ducos7,8, M. Bonnet1, A.Bensussan1,2, A. Patatian5, E. Lati5,6, J. Wdzieczak-Bakala9, J-C. Choulot10, E. Loing11, M. Hocquaux11.

1 Inserm UMR976, Skin Research Institute, F-75475 Paris, France

2 Univ. Paris Diderot, Sorbonne Paris-Cité, Hôpital Saint-Louis, F-75475 Paris, France

3 Centre Sabouraud, F-75475 Paris, France

4 NICN UMR 7259 CNRS Faculté de médecine 13344 Marseille, France

5 GENEX, 91160 Longjumeau, France

6 Laboratoire BIO-EC, 91160 Longjumeau, France

7 Plateforme de qPCR à Haut Débit Genomic Paris Centre, IBENS, 75005 Paris, France

8 Laboratoire de Physique Statistique, École Normale Supérieure, PSL Research University,

Univ. Paris Diderot, Sorbonne Paris-Cité, CNRS, 75005 Paris, France

9 ICSN, 91198 Gif-sur-Yvette, France

10 Ales groupe, 95871 Bezons, France

11 IEB-Lucas Meyer Cosmetics, 31520 Ramonville, France

Br J Dermatol. 2017 Nov;177(5):1322-1336


Anti-ageing activity of Fitchia nutans extract, a cosmeceutical ingredient of a Polynesian traditional monoï.

Ansel JL1,2, Ly Q1, Butaud JF3, Nicolas M1,4, Herbette G5, Peno-Mazzarino L6, Lati E6, Raharivelomanana P1

1EIO, UMR241, Université de la Polynésie Française, Tahiti, France

2Cosmetic Valley, Chartres, France

3Consultant en foresterie et botanique polynésienne, Tahiti, France

4Geoazur, UMR7329, Université Sophia Antipolis, Valbonne, France

5Spectropole, FR1739, Université Aix-Marseille, Marseille, France

6BIO-EC Laboratory, Longjumeau, France

Comptes rendus Chimie (2016, in press)


Pilot Comparative Study of the Topical Action of a Novel, Crosslinked Resilient Hyaluronic Acid on Skin Hydration and Barrier Function in a Dynamic, Three-Dimensional Human Explant Model.

Sundaram H1, Mackiewicz N2, Burton E2, Peno-Mazzarino L3, Lati E3, Meunier S2.

1Dermatology, Cosmetic & Laser Surgery, Rockville, MD

2Teoxane SA, R&D Department, Geneva, Switzerland

3Laboratoire BIO-EC, Longjumeau, France

Journal of Drugs in Dermatology, 2016;15(4):434-441.


Impact of a commonly used skin irritant on cornified envelope and cellular junction expression and localization

Percoco Giuseppe, Peno-Mazzarino Laurent, Durand Caroline, Gasser Philippe, Scalvino Stephanie, Reby Doriane and Lati Elian

Personal care magazine 6th Avril 2016


The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.

Asserin J1, Lati E2, Shioya T3, Prawitt J4.

1COSderma Laboratory, Bordeaux, France.

2BIO-EC Laboratory, Longjumeau, France.

3Unitec Foods, Tokyo, Japan.

4Rousselot BVBA, Gent, Belgium.

Journal of Cosmetic Dermatology, 2015 Vol 14, Issue 4, pages 291–301


Pseudomonas fluorescens, a forgotten member of the human cutaneous

microflora sensible to skin communication and defense peptides

Mélanie Hillion1#, Lily Mijouin1#, Awa N’Diaye1, Giuseppe Percoco2,3, Jérémy Enault1, Marie-Laure Follet-Gueye2, Florent Yvergnaux4, Luc Lefeuvre5 & Marc G.J. Feuilloley1,*

# Contributed equally to this work

1Laboratory of Microbiology Signals and Microenvironnement LMSM, EA 4312, Normandie Univ.; Univ. Rouen, Evreux, France,

2GlycoMev EA 4358, Normandie Univ.; Univ. Rouen, Mont-Saint-Aignan, France,

3Bio-EC Laboratory, F-91165 Longjumeau, France,

4BioEurope Groupe Solabia, Anet, France,

5Dermatologic Laboratories Uriage, Courbevoie, France

ISSN: 2319-7706 Volume 3 Number 7 (2014) pp. 910-925


Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (Centevita™).

Maramaldi G1, Togni S1, Franceschi F1, Lati E2.

1Indena SpA, Milan, Italy

2Laboratoire BIO-EC, Longjumeau, France

Clinical, Cosmetic and Investigational Dermatology, 2013, 7: 1–9.


Effects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora.

Lily Mijouin,1 Mélanie Hillion,1 Yasmina Ramdani,2 Thomas Jaouen,1 Cécile Duclairoir-Poc,1 Marie-Laure Follet-Gueye,2 Elian Lati,3 Florent Yvergnaux,4 Azzedine Driouich,2 Luc Lefeuvre,5 Christine Farmer,1 Laurent Misery,6,7 and Marc G. J. Feuilloley1

1Laboratory of Microbiology Signals and Microenvironnement LMSM, EA 4312, Normandie Université, Université Rouen, Evreux, France

2GlycoMev EA 4358, Normandie Université, Université Rouen, Mont-Saint-Aignan, France

3BIO-EC Laboratory, Longjumeau, France

4BioEurope Research, Anet, France

5Dermatologic Laboratories Uriage, Courbevoie, France

6EA 4685 University of Western Britanny, Brest, France

7Department of Dermatology, University Hospital of Brest, Brest, France

PLoS One. 2013; 8(11): e78773.


Comparative study of normal and sensitive skin aerobic bacterial populations.

Mélanie Hillion,1 Lily Mijouin,1 Thomas Jaouen,1 Magalie Barreau,1 Pauline Meunier,2 Luc Lefeuvre,3 Elian Lati,2 Sylvie Chevalier,1 and Marc G J Feuilloley1

1Laboratory of Microbiology Signals and Microenvironment EA 4312, University of Rouen, 27000, Evreux, France

2BIO-EC Laboratory, 92140, Longjumeau, France

3Dermatologic Laboratory URIAGE, BP50 92404, Courbevoie Cedex, France

MicrobiologyOpen, 2013 ; 2(6): 953–961


Antimicrobial peptides and pro-inflammatory cytokines are differentially regulated across epidermal layers following bacterial stimuli.

Giuseppe Percoco1,2, Chloé Merle2, Thomas Jaouen3, Yasmina Ramdani1, Magalie Bénard4, Mélanie Hillion3, Lily Mijouin3, Elian Lati2, Marc Feuilloley3, Luc Lefeuvre5, Azeddine Driouich1,4 and Marie-Laure Follet-Gueye1,4

1Glycobiology and Plant Extracellular Matrix (GlycoMEV) Laboratory, UPRES EA 4358, University of Rouen, Mont-Saint-Aignan, France

2BIO-EC Laboratory, Longjumeau, France

3Microbiology Signals and Microenvironment (LMSM) Laboratory, UPRES EA 4312, University of Rouen, Evreux, France

4The Cell Imaging Platform of Normandy (PRIMACEN), Institute of research and biomedical innovation (IRIB), University of Rouen, Mont-Saint-Aignan, France

5Dermatological Laboratories of Uriage, Courbevoie, France

Experimental Dermatology, (2013) 22: 800–806. doi: 10.1111/exd.12259


The regulatory role of the tetrapeptide AcSDKP in skin and hair physiology and the prevention of ageing effects in these tissues – a potential cosmetic role

N. Hajem1,2, A. Chapelle1, J. Bignon1, A. Pinault1, J.-M. Liu1, N. Salah-Mohellibi3, E. Lati4 and J. Wdzieczak-Bakala1

1Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

2ALES GROUPE, Bezons, France

3CEA, iRCM, Laboratoire de Génomique et Radiobiologie de la Kératinopoïèse, Evry, France

4Laboratoire BIO-EC, Longjumeau, France

International J. of Cosmetic Science, 2013, 35: 286–298. doi: 10.1111/ics.12046


Isolation of human epidermal layers by laser capture microdissection: application to the analysis of gene expression by quantitative real-time PCR

Giuseppe Percoco1, Magalie Bénard2, Yasmina Ramdani1, Elian Lati3, Luc Lefeuvre4, Azeddine Driouich1,2 and Marie-Laure Follet-Gueye1,2

1Glycobiology and Plant Extracellular Matrix (GlycoMEV) Laboratory, UPRES EA 4358, IFRMP 23, University of Rouen, Mont-Saint-Aignan, France

2The Cell Imaging Platform of Normandy (PRIMACEN), IFRMP23, University of Rouen, Mont-Saint-Aignan, France

3BIO-EC laboratory, Longjumeau, France

4Laboratoires Dermatologique d’Uriage, Courbevoie, France

Experimental Dermatology, 2012, 21: 531–534. doi: 10.1111/j.1600-0625.2012.01509.x


Experimental 70% hydrofluoric acid burns: histological observations in an established human skin explants ex vivo model

François Burgher,1 Laurence Mathieu,1 Elian Lati,2 Philippe Gasser,2 Laurent Peno-Mazzarino,2 Joël Blomet,1 Alan H Hall,3 and Howard I Maibach4

1 Scientific Action Group, Prevor Laboratory, Valmondois, France

2 BIO-EC Laboratory, Longjumeau, France

3 Toxicology Consulting and Medical Translating Services, Inc., Laramie, Wyoming and Colorado School of Public Health, Denver, Colorado, USA

4 Department of Dermatology, University of California-San Francisco, San Francisco, California, USA

Cutaneous and ocular toxicology, 2011, 30(2): 100–107.

Part 2. Comparison of emergency washing solutions in 70% hydrofluoric acid-burned human skin in an established ex vivo explants model

François Burgher,1 Laurence Mathieu,1 Elian Lati,2 Philippe Gasser,2 Laurent Peno-Mazzarino,2 Joël Blomet,1 Alan H Hall,3 and Howard I Maibach4

1Scientific Action Group, Prevor Laboratory, Valmondois, France

2BIO-EC Laboratory, Longjumeau, France

3Toxicology Consulting and Medical Translating Services, Inc., Laramie, WY, USA and Colorado School of Public Health, Denver, CO, USA

4Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA

Cutaneous and Ocular Toxicology, 2011 Jun; 30(2): 108–115.

Glycation induction and antiglycation activity of skin care ingredients on living human skin explants

P. Gasser1, F. Arnold2, L. Peno-Mazzarino1, D. Bouzoud1, M. T. Luu3, E. Lati1 and M. Mercier3

1BIO-EC Laboratory, Longjumeau, France

2MMP SARL, Issy les Moulineaux, France

3MMP Inc., South Plainfield, New Jersey, U.S.A.

International Journal of Cosmetic Science, 2011, 33: 366–370. doi: 10.1111/j.1468-2494.2011.00640.x


Cocoa polyphenols, chemical structure and their influence on parameters involved in ex vivo skin restructuring

Gasser, P.1, Lati, E.1, Peno-Mazzarino, L.1, Bouzoud, D.1, Allegaert, L.2, Bernaert, H.2

1 BIO-EC Laboratory, 92140 Clamart, France

2 Barry Callebaut, Aalstersestraat 122, 9280 Lebbeke, Belgium

International Journal of Cosmetic Science, 2008, 1–7

La peau support des cosmétiques, mais aussi support d’évaluation

P. Gasser, D. Bouzoud Laboratoire BIO-EC

L’actualité chimique oct-nov 2008 n°323-324

Calcium improves skin health

Evelyne Lopez1, Elian Lati2, Philippe Gasser2, Marthe Rousseau1

1Museum National d’Histoire Naturelle Département Milieux et Peuplements Aquatiques USM 0401, UMR 5178 ‘Biologie des Organismes Marins et Ecosystèmes’

2BIO-EC Laboratory, Longjumeau, France

Household and Personal Care Today n 3/2008


Restoration of stratum corneum with nacre lipids

Marthe Rousseau1, Laurent Bédouet1, Elian Lati2, Philippe Gasser2,

Karine Le Ny1, Evelyne Lopez1

1Muséum National d’Histoire Naturelle, Département des Milieux et Peuplements Aquatiques, UMR 5178, CNRS-MNHN «Biologie des Organismes Marins et Ecosystèmes»

2Laboratoire BIO-EC, Longjumeau, France

Comparative Biochemistry and Physiology, Part B 145 (2006) 1–9

Human keratinocyte radiosensitivity is linked to redox modulation

Muriel Isoire2, Valérie Buard1, Philippe Gasser2, Philippe Voisin1, Elian Lati2, Marc Benderitter2

1Institut de Radioprotection et de Sûreté Nucléaire IRSN, Service de Radiobiologie d’Epidémiologie, Direction de la Radioprotection de l’Homme, Laboratoire de RadioPathologie, IRSN, B.P. no. 17, F-92262 Fontenay-aux-Roses Cedex, France

2Laboratoire BIO-EC, Centre de Recherches et d’Expérimentations Cutanées, Clamart, France

Journal of Dermatological Science, 2006, Vol 41, Issue 1, Pages 55–65


Original semiologic standardized evaluation of stratum corneum hydration by Diagnoskin® stripping sample

P. Gasser1, L. Peno-Mazzarino1, E. Lati1 and B. Djian2

1 Centre de Recherches Biologiques et d’Expérimentation Cutanées, Laboratoire BIO-EC, Clamart

2 Dermatologist 54, avenue Kleber 75116, Paris, France

International Journal of Cosmetic Science, 2004, Vol 26, Issue 3, pages 117–127

Etude des effets protecteurs d’une crème barrière vis à vis de la pénétration cutanée du nitrate de nickel

Lati E1, Gasser P1, Lefeuvre L2, Matta AM2, Gougerot A2

1BIO-EC Laboratory, Clamart, France

2Laboratoires Dermatologiques URIAGE – 98, avenue de la République – 92400 Courbevoie

Les Nouvelles Dermatologiques 2004; 23 : 208-213


Control of chondrocyte phenotype in a chitosan/chondrocyte construct

Korwin-Zmijowska C1, Tahiri K1, Gasser P2, Morfin I2, Hazot P2, Domard A2, Soler C3, Guillot F3, Chevalier X1, Corvol MT1

1INSERM U530, UFR Biomédicale des Saint Pères, 75270 Paris, France

2CNRS UMR5627, ISTIL, Université Claude Bernard, Villeurbanne, France

3Laboatoire Genévrier, Sophia Antipolis, Nice, France

4BIO-EC Laboratory, France

European Cells and Materials Vol4, Suppl. 1, 2002, pages 18-19